This exceptional reference examines current and emerging topical and transdermal drug delivery systems and their influence on the uptake, absorption, and potency of released compounds. It presents detailed information on such important topics as the kinetic properties and chemical interactions of the skin, drug candidate, and transport vehicle to avoid skin irritation and inflammation, and enhance drug performance and distribution. Containing more than 1,700 references, tables, and equations. Transdermal drug delivery, 2nd Ed. is a timely source for industrial, clinical, and research pharmacists.

This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of delivery routes, found in areas like: Oral Ocular Dermal and transdermal Vaginal Colonic Oral mucosal Nasal Pulmonary Providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value, topics include: modified drug release landscape; academic, regulatory, and intellectual property viewpoints I-vation Sustained Release Intravitreal System ViaNase Intranasal Device and controlled particle dispersion technology Platform Microneedles for drug delivery, PassPort system, Dot-Matrix technology, ultrasound, iontophoretic and technologies, DiretcHaler Nasal technology, intravaginal ring systems, Supravail, Vagisite, C-Vad (TM) Vaginal Insert, and 'Smart' Vaginal Delivery Systems the AERx (R) Pulmonary Drug Delivery System AAD-Adaptive aerosol delivery technology nebulizer technologies and dry powder inhaler systems

This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of delivery routes, found in areas like:

• Oral
• Ocular
• Dermal and transdermal
• Vaginal
• Colonic
• Oral mucosal
• Nasal
• Pulmonary

Providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value, topics include:

• Intellectual property rights and regulatory issues and challenges
• osmotic systems and Qtrol. Qdis. Matrix Systems
• thiolated polymers for CR, Oradur. IDD technology, and chronotherapy technology
• Oral-lyn (RapidMist Technology)
• Dentipatch drug delivery system
• ORAVESCENT: a novel technology for the transmucosal delivery of drugs
• Egalet and COLAL technologies

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulatory approval.

Because of the slow and costly process of developing new blockbuster drugs, pharmaceutical scientists are increasingly charged with reformulating existing drugs in order to expand a company's market opportunity and to sustain company growth. This presents an opportunity for formulation scientists to innovate and develop novel drug delivery systems to extend the commercial life of existing drugs. Divided into two volumes, this "Second Edition" describes the anatomical, physiological, pharmaceutical, and technological aspects of oral, colonic and rectal, ocular, oral mucosal, dermal and transdermal, nasal, vaginal, and pulmonary delivery routes, providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value.

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